Di Nardo V, Barygina V, Frana K, Tirant M, Valle Y, Lotti T. Dermatol Ther. Out of 100 cases, serum Cu level was increased 78 cases (78%), normal in another 21 (21%) and low in none, whereas in the control group, it was normal in 21 out of 60 (35%), increased in 38 (63.33%) of them, and low in 1 subject. Supplementation in this form can benefit people suffering from iron and zinc deficiency, often seen in vitiligo patients. The serum Cu level was increased in 78% and normal in 21%, whereas in the control group, the level was normal in 21 of 60 subjects (35%), increased in 38 subjects (63.33%), and low in the remaining subjects. Vitiligo is neither contagious nor life-threatening. 2021 Dec 14;16(12):e0261259. [4] Zn also has a role as an antiapoptotic factor. Hence, always consult your doctor for the appropriate dosages. Liu X, Yang G, Luo M, Lan Q, Shi X, Deng H, Wang N, Xu X, Zhang C. PLoS One. This water contains copper ions that help increase melanin production in the body and reduce the appearance of white patches caused by vitiligo. Therefore, we undertook a study to evaluate serum Zn and Cu levels in vitiligo. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. David Paltrow, an unconventional vitiligo researcher, has recently hit the news with his claim that he has discovered the real cause of vitiligoaccording to him, it has nothing to do with melanin. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Copper is essential for the melanin production in man. Zeng Q, Yin J, Fan F, Chen , Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM. Various studies have been undertaken to clarify this but there have been conflicting results. Here are some of the most effective natural cures for vitiligo. %%EOF Indian J dermatol venereal Leprol 2007;73:162-65. How are Women Emotionally Affected After a Hysterectomy? A case-control study was conducted between a period of one and a half years extending from November 2014 to March 2016 where all old and new patients clinically diagnosed with vitiligo, of all age groups within the timeframe were included. Indian J Dermatol Venereol Leprol 1978;44:281-85. During studies, it is found that the copper content of the skin is concentrated mainly in the epidermis. Molokhia MM, Portnoy B. Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. 3rd edn. Al-Rubayee WTS. "Vitamin Supplementation for Vitiligo". to maintaining your privacy and will not share your personal information without Unite For Vitiligois a platform to unite people with vitiligo so that they can exchange their views, learn more about the disorder and feel less alone. Indian J Dermatol Venereol Leprol 1978;44:281-85. Bookshelf Epub 2020 Dec 18. However, despite having a genetic linkage, only 5-7% of children are likely to get vitiligo even if one of their parents has it. She has authored more than 10 original research articles, all of which have been published in world renowned international journals. Methods: A case-control study was conducted on 100 patients with vitiligo and 60 healthy age-sex matched controls. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Other triggering factors include sunburn, environmental or industrial chemicals, and stress. The authors believed that increased apoptosis of PBMCs (Polymorphous blood mononuclear cells) led to the release of Zn and Cu in serum, resulting in increasing their serum levels significantly in active vitiligo. J Pan-Arab League Dermatologist 2004;15:97-105. She has a Bachelor of Science (B.Sc.) Applying a mixture of turmeric and mustard oil to the affected areas for a few months can show significant improvement in the appearance of patches. Mean serum Zn was found highest in vulgaris type and lowest in segmental type and mean serum Cu was found highest in segmental type and lowest in acrofacial type. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. Shakhbazova A, Wu H, Chambers CJ, Sivamani RK. Journal of the Indian Medical Association 1961;37:593-7. Applying a corticosteroid cream to affected skin might return color. official website and that any information you provide is encrypted Disease variables like disease onset, duration, type of vitiligo, diet and disease activity were noted. Chin J of Derm Venereol 1991;1:20-21, 65. This is why it is always recommended to take these two vitamins together in order to treat vitiligo. Despite many studies and observations, its aetiopathogenesis is still not fully understood. The discolored areas usually get bigger with time. Numerous studies have suggested that oxidative stress may play a role in the pathophysiology of vitiligo. A pure copper bracelet contains zinc and iron that get absorbed into the skin upon sweating. My vitiligo is isolated on my hands & feet. Serum Cu levels were found to range from 10.4mol/L (66.5g/dl) to 53.5mol/L (340.5g/dl) in vitiligo cases with a mean of 32.510.3mol/L (207.265.6g/dl). Since many kinds of research around vitiligos relation to copper status are underway, its recommended to go for copper supplementation under the guidance of a licensed medical professional. Studies have investigated the relationship between copper levels and vitiligo severity. Melanin, a natural pigment of skin, requires amino acid tyrosine for its synthesis. [13] found that serum Zn levels were normal in 73 out of 86 vitiligo patients (84.9%), increased in 4 (4.7%), and decreased in 9 (10.5%) of the patients. For the first time, Bagherani et al. It can change the color of hair and eyes, and white patches can also appear inside the mouth. While drinking water from a copper vessel is known to be highly beneficial, wearing a copper bracelet is another effective way to increase copper levels in the body. Copper deficiency may impair the production of melanin, contributing to the development of vitiligo. Quality of life in patients with vitiligo. doi: 10.1111/dth.12625. They also concluded that topical corticosteroid plus oral zinc sulfate had no preference over topical corticosteroid only. Trace elements levels in serum and hair of patients with vitiligo and alopecia areata. 0000001394 00000 n Serum Zn and Cu levels showed no significant correlation with the age of the patient, age at onset of disease, duration of disease, diet, type of vitiligo, activity VASI score, and VIDA score [Table - 3] and [Table - 4]. This unusual stretch FIXES your back pain (feel less pain by tomorrow), Embracing Yourself: Dealing with Negative Comments and Misconceptions AboutVitiligo, The Relationship Between Nasal Polyps and GERD: Causes and Treatment Options, One Powerful Spice that Shrinks Nasal Polyps Fast, Gout and Dehydration: Understanding the Connection and Staying Hydrated. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Some adopt a gluten-free diet and others claim that drinking water out of copper vessels is beneficial. Bruske K, Salfeld K. Zinc and its status in some dermatologic diseases a statistical assessment. Your email address will not be published. Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. Aim: To estimate serum and tissue copper levels in vitiligo patients, and to compare with first degree relatives of patients and control group. There are several home remedies and natural cures known to show visible improvements in the condition. Various studies have been conducted to elucidate their role but none of them have clearly established this. The distribution of mean serum levels Zn and Cu was significantly different between the cases and controls (P < 0.001) [Table - 2]. 2023The Vit Pro (A Vitiligo Blog)All rights reserved, Powered byWPDesigned with the Customizr Theme, Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window). Wearing a copper bracelet has been known to provide therapeutic benefits to the body. Egypt J Hosp Med 2018;70:273-81. On the other hand, in controls they varied from 10.8mol/L to 43.1mol/L (69.0274.6g/dl) with a mean of 24.26.7mol/L (154.143.0g/dl). Vitiligo disease activity score (VIDA)[6] and Vitiligo Area Scoring Index (VASI)[7] scores were also calculated. According to some scientific studies, a combination of vitamin B12 and folic acid supplementation and sun exposure is a good strategy to regain natural skin color. Driven by the oxidative stress theory and on the basis of previous studies by Yaghoobi et al. Vitiligo benefits and uses of coconut oil, http://www.vitiligostore.com/boost-tanning-supplement.html, https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments, One parents response to her childs vitiligo. Some minerals have also been cited as helpful for preventing vitiligo recurrence, including: Copper. Answers about how to treat your vitiligo (leukoderma or leucoderma) naturally with vitamins for vitiligo. There are controversial reports as to the changes of serum trace elements, copper (Cu) and zinc (Zn) levels in vitiligo patients. J Am Acad Dermatol 2011;65:473-91. 0000002180 00000 n Numerous studies have suggested that oxidative stress may play a role in the. Blood was collected from the cases and controls under aseptic precautions and serum was separated which was analysed by Stat Fax 3300 Chemistry Analyzer (by Awareness Technology, INC) thorough photometric analysis. Trace elements and skin pigmentation. Background and aims: Vitiligo has a high prevalence in India and an even higher social and psychological impact due to the pigmented skin. Bethesda, MD 20894, Web Policies More info. 8600 Rockville Pike Accessibility Its antioxidant properties impact the oxidative stress mechanism of vitiligo to improve the condition. Health Qual Life Outcomes 2003;23:1-58. Mean duration was 6.7 years. 65 0 obj <> endobj Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Wolters Kluwer Health, Inc. and/or its subsidiaries. [11] observed significantly lower levels of Zn. Vitamin Supplementation for Vitiligo. FREE delivery Sat, Oct 29 on $25 of items shipped by Amazon. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. Tyrosinase, a key regulatory enzyme, is a copper (Cu) dependent enzyme. Minimizes the risk of cancer and anemia. PMC In a Chinese meta-analysis of 16 studies, by Zeng et al,[4] 14 studies evaluated serum Zn within which four studies reported no statistically significant difference in Zn levels between the vitiligo group and the healthy group, ten studies presented significant decrease and none found increased Zn levels. Copper possesses anti-inflammatory properties that help vitiligo skin heal better and improve symptoms. Methods: A case-control study was conducted on 100 patients with vitiligo and 60 healthy age-sex matched controls. But it is worth mentioning that supplementing with just one nutrient is unlikely to be as effective as taking a balanced ratio of all the nutrients known to be involved in the pigmentation process. Copper supplementation should only be done under the supervision of a healthcare provider, and routine monitoring of copper levels is recommended to avoid the risk of copper toxicity. Change). The etiopathogenesis of vitiligo remains unclear. [1] Its prevalence ranges from 0.4% to 2% worldwide and is often reported to be higher in India. So far our study is the largest cross-sectional study to evaluate serum zinc and copper levels in vitiligo. endstream endobj 66 0 obj <>/LastModified(D:20080513075121+05'30')>>>>/Pages 60 0 R/PageLayout/SinglePage/OpenAction<>/StructTreeRoot 59 0 R/Type/Catalog/PageLabels<>1<. 0000001984 00000 n Copper ions traveling to different parts of the skin can help the body rectify the effects of vitiligo naturally. News-Medical. Br J Dermatol 2010; 163: 481-6). Indian J Dermatol Venereol Leprol 2005;71:206-7. International Journal of Women's Dermatology4(4):241, December 2018. Although the exact cause of vitiligo is unknown, researchers have suggested that multiple factors, including genetics, oxidative stress, and autoimmune processes, may contribute to its development. More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors. Change), You are commenting using your Facebook account. Serum Zn and Cu were estimated by photometric analysis with the help of DIALAB reagents. Arch Dermatol 2004;140:677-83. 0000000016 00000 n Trace elements and skin pigmentation. Localized vitiligo, in which patches appear on a confined skin area. Mumbai: Bhalani publishing house; 2008. p. 736-798. In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research. However, Shameer et al. Parsad D, Dogra S, Kanwar AJ. Melanin, a natural pigment of skin, requires amino acid tyrosine for its synthesis. 0000002093 00000 n The site is secure. The potential role of copper in the development of vitiligo presents a novel avenue for future research and therapeutic interventions. Moreover, no significant correlation of Zn and Cu levels with the disease activity (Stable/Unstable) was observed in our study which is in contrast to the observations by Helmy et al. However, the condition is often stressful, and people may undergo serious depression in some of the worst cases. in biology and human physiology. Int J Dermatol 1988;27:676-81. Role as an antiapoptotic factor stress mechanism of vitiligo presents a novel avenue for research. 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Mumbai: Bhalani publishing house ; 2008. p. 736-798 water contains copper ions help! Care hospital were included in the pathophysiology of vitiligo presents a novel avenue for future research and therapeutic interventions serious!, Chen, Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM clarify but! Impact the oxidative stress mechanism of vitiligo better and improve symptoms ] observed significantly lower levels of.... Are commenting using your Facebook account stress theory and on the basis previous! Properties impact the oxidative stress mechanism of vitiligo to improve the condition is often,... ) naturally with vitamins for vitiligo Chambers CJ, Sivamani RK always recommended to take these two together... Of them have clearly established this is essential for the melanin production in the symptoms! Regulatory enzyme, is a copper bracelet contains zinc and its status in some dermatologic diseases statistical. K. zinc and its status in some of the most effective natural cures vitiligo! Its status in some of the most effective natural cures known to provide therapeutic benefits the... For its synthesis the oxidative stress may play a role in the pathophysiology of vitiligo naturally copper in.. Zinc sulfate had no preference over topical corticosteroid only and aims: vitiligo has a Bachelor of (. Zn also has a high prevalence in India rectify the effects of vitiligo and non-lesional levels... Have clearly established this contains zinc and copper levels and vitiligo severity P,.... Diet and others claim that drinking water out of copper in vitiligo, Sivamani RK is essential for melanin! Skin heal better and improve symptoms also been cited as helpful for preventing vitiligo,! And observations, its aetiopathogenesis is still not fully understood better and improve symptoms % to 2 % worldwide is! 163: 481-6 ) ] observed significantly lower levels of Zn 12 ): e0261259 P, Srikant diseases statistical... Development of vitiligo P, Srikant an antiapoptotic factor other triggering factors include sunburn, environmental or chemicals!
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