Alpha GPC Review: Benefits, Side Effects, and Dosage Guide, https://www.ncbi.nlm.nih.gov/pubmed/12637119, https://www.ncbi.nlm.nih.gov/pubmed/22673596, https://www.ncbi.nlm.nih.gov/pubmed/1916007, https://www.ncbi.nlm.nih.gov/pubmed/8030842, https://www.ncbi.nlm.nih.gov/pubmed/1662399, https://www.ncbi.nlm.nih.gov/pubmed/2071257, Improved focus, concentration, memory, and cognitive function, Increased mental clarity and brain fog reduction through acetylcholine synthesis, Enhanced mental and physical endurance and lessening of fatigue, Improvements in physical power output and recovery after overexertion, Enhanced fat oxidation and production of human growth hormone in young adults, Neuroprotective properties to shield and preserve an aging brain, Substantial cognitive improvements in dementia disorders of the Alzheimers type patients, or those suffering from other neurodegenerative diseases. The recommended dosage for Alpha-GPC will depend on the users goal. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. The artificial sweetener aspartame also contains Phenylalanine. In a study involving 32 healthy young volunteers, alpha GPC effectively restored memory following temporary chemically-induced amnesia.[4], Anecdotal experience reports affirm that alpha GPC is an effective nootropic that provides a powerful cognitive boost, along with increased energy and motivation.[5][6][7]. Wang Z, Hazen J, Jia X, et al. The nutritional supplement L-alpha glycerylphosphorylcholine promotes atherosclerosis. (Harvard Medical School and McClean Hospital - 7), 3. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. If you're looking to stack Alpha-GPC with other supplements, we recommend NooCube. Daily dosing of 300-1200mg cumulatively has been documented as safe and effective for most users. When we form long-term memories, we use proteins to "solidify" the link in our neural network. Another potential side effect of alpha GPC is it could increase the risk for strokes. For most adults, the range of acceptable dosage is fairly wide; a cumulative daily dosage of 3001200 mg taken in one to three doses has been documented as safe and effective. Choline is an essential nutrient for brain health, and it's involved in a number of cognitive processes like memory formation and neural signaling. As a nootropic, Alpha GPC is light years ahead of Choline bitartrate. Alpha GPC has been shown to have a positive increase on memory retention, as well as a negative impact on cognitive decline. Your age and personal health also play a role. Though many of its benefits are cognition-oriented and related to its cholinergic properties, it has also been shown to promote physical health and muscular strength. 5. Mol Cell Biochem. But I haven't taken any in a while; I find that there are diminishing marginal returns. We wont dive into detail on the other two choline sources. For strictly Choline supplementation, Alpha GPC tends to be the more popular choice. An Italian multicenter clinical trial., Traini, Enea et al. In the event of an Alpha GPC overdose, some users may experience the following side effects: Headaches, insomnia, dizziness, skin rash, heartburn, sweating, salivation, nausea, or decreased appetite. This information may not fit your specific health circumstances. Simply reduce Alpha GPC intake back to an acceptable amount for your body. This double-blind, placebo-controlled trial used 80 human subjects evenly split between male and female. 1. Cogmetics Ltd.Sovereign House Flat 1 Grand ParadeBN21 3YP EastbourneUnited Kingdom. This supplement also works to improve your overall mental clarity and focus which is what makes it so great for people that are trying to study or do work! Let us know about your experience with Alpha GPC in the comments below! They aren't for human consumption, nor medical, veterinary, or household uses. They typically only surface when going far beyond the recommended dose. But this stuff has got me fully awake and in a great mood at 2 am and looking forward to my workout. Throughout, they were given psychometric tests, including on word fluency, depression, memory scale, and more. Deep Dive on Lutein: Your Eyes' Best friend, Nootropics For Anxiety - How To Solve Your Problems, How To Take Energy Supplements - 5 Mistakes You Must Avoid, How Much Collagen Should I Take The Ultimate Guide. Join our Newsletter and get a free copy of our ebook The Encyclopedia of Nootropics. Its primarily known for its nootropic properties such as memory enhancement and neuroprotection. Two common types are CDP-Choline (Citicoline) and Choline Bitartrate / Lecithin. But, the real strength comes from its potentiating properties when stacked with other smart pills and nootropics. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study., De Jesus Moreno Moreno, Maria. In this section, we will outline some of the major studies as they related to the two main areas of effectiveness of Alpha GPC memory & cognition and physical performance. Alpha GPC also increasesphosphatidylcholine levels throughout the body, which promotes strong cell structure, supports nerve signaling, and helps maintain the brains neurochemical balance. Tayebati SK, Di Tullio MA, Tomassoni D, Amenta F. Choline is considered a dietary supplement in the United States, with a composition similar to that of the B vitamin complex. In Europe, choline is regulated and sold under the brand names Delecit and Gliatilin with prescriptions. It is best to aim for a ratio of between 4:1 and 8:1 in favor of Piracetam. The side effects of Alpha GPC listed below are rare. For attenuating symptoms of cognitive decline, almost all studies used a dosage of 1,200 mg per day, divided into three doses of 400 mg. For boosting power output, studies have used a dosage of 300600 mg, supplemented 3060 minutes prior to exercise. 250mg of Citicoline would provide 46mg of Choline. Finding your optimal dosage: Some people have seen better results from exceeding the "official" recommended dose. This is our main nerve messenger, according to Dr. Zeisel. The benefits of Alpha-GPC for cognition can be attributed to its ability to increase levels of acetylcholine in the brain. Alpha-GPC, also known as choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a natural choline compound found in the brain. It is a reliable supplement which is taken by people for athletic reasons, cognition reasons, and beyond. 1. What Is The Recommended Dosage For Alpha-GPC? You can also find it in some energy drinks and pre-workout supplements, making it perfect for people who want a little extra boost of energy and focus. Alpha GPC is generally well tolerated when taken at recommended dosages. In general, this Alpha GPC dose is both recommended and well-tolerated. Important Notice: The compounds and products found on WholisticResearch are for research purpose only. Alpha-GPC (alpha-glycerophosphocholine or choline alphoscerate) is a choline-containing phospholipid. Alpha-GPC is generally well tolerated. Alpha GPC has a half-life of 4-6 hours (this is how long it lasts in your body), which is why you should take it throughout the day instead of all at once. The results of the trial suggested that Alpha GPC produced a definite symptomatic improvement. View abstract. Consider these factors before deciding whether and how much Alpha GPC to consume. Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports. However, choline concentrations high enough for nootropic benefits such as improving focus require supplementation. If you are still in doubt, the option is always available to consult a physician or a dietician for more information. Alpha GPC has a reported half-life of 4-6 hours and can potentially penetrate the blood-brain barrier. Alpha GPC stacks very well with the top supplements for energy. We recommend buying Alpha-GPC from a reputable vendor like Pure Nootropics. Alpha-GPC is also effective at boosting physical performance. Take your time to decide what you are looking for out of a supplement routine, and compare it to our extensive outline above. In an interview, Dr. Steven Zeisel from UNC said that Choline performs 2 key roles: 1. As a result, Choline accumulates in the system. Planning to start a new supplementation regimen? Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a chemical made in the body from choline. Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure- Induced Neuronal Death., Morell, P, and A H Ousley. [2], Oral supplementation of alpha-GPC is primarily of interest for nootropic or cognitive-enhancement purposes. (The University of Barcelona - 8), Researchers observed that Alpha GPC increases the activation of striatal dopaminergic output. Researchers have also found that people who suffer from Alzheimer's disease and dementia may experience some benefits from taking Alpha-GPC. 2. The most common side effect is headaches, which is often a sign of too much choline in the system. The dosing recommendations below refer to the total amount of Alpha GPC ingested not the 40% choline output. Once youve assessed tolerance and effect, you may increase your dose in a stepwise fashion. Your brain converts L-Tyrosine to L-DOPA which then produces the neurotransmitter dopamine. Choline: needed for normal development of memory J Am Coll Nutr. Alpha-GPC, is 40% choline by weight as well. The extra choline helps you be more attentive and clear-headed, thus increasing feelings of well-being. The myelin sheath acts as an insulator, which helps to protect the nerve fibers and ensure that the electrical signals can travel quickly and efficiently. It has powerful benefits for both the brain and body and may enhance the full range of cognitive functions, promote cellular health, and help maintain essential neurochemical balance in the brain.[1]. For performance-enhancing benefits through acute supplementation: 600 mg of alpha-GPC taken 30-90 minutes before exercise is optimal. Other studies have suggested that Alpha GPC can improve memory formation as well as learning ability. Alpha-GPC is used for a variety of purposes, including: In clinical settings, Alpha-GPC has been shown to be effective in improving cognitive function and memory, as well as treating Alzheimer's disease and dementia (8). Phoshpolipids are the raw materials we use to repair brain-cell membranes. 3. The pros of using Alpha-GPC as a nootropic supplement include: It's an effective cognitive enhancer, it's generally safe, and it has few side effects. Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. Its been the subject of decades of research. It works by increasing levels of acetylcholine, a neurotransmitter critical for learning and memory. If you happen to experience any of these side effects, youve gone too far in your dose. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Given these long-term health benefits and cognitive boosting abilities, Alpha GPC becomes vital for building a sharper mind. 2. CDP Choline also breaks down into Uridine: This is the reason why Citicoline is only 18.5% Choline by weight. That includes things like planning, organizing and managing time. Uridine Monophosphate (UMP or 5-uridylic acid) is a pyrimidine nucleoside found in all living organisms ranging from humans to bacteria. Alpha GPC has a shorter half-life than CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). Not only does Choline repair brain-cells, it creates Acetylcholine. ( 7) Beyond increasing muscle strength and physical force, growth hormone is also known to enhance weight loss, strengthen bones, boost mood and improve sleep quality. This speaks to its ability to improve brain health and cognition levels. Alpha-GPC is a common nootropic. I thought it was simply a "Go-along" to support the benefits of the racetam I'm already taking (phenylpiracetam). Acetylcholine is dubbed the learning neurotransmitter and is responsible for just that memory and learning. It is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe and Russia for various memory and cognitive disorders. Daily dosing of 300-1200mg is once again recommended for this purpose. Alpha-GPC is a non-essential nutrient, which means that your body can produce it on its own. It is possible that alpha-GPC decreases the effects of scopolamine, but it's not clear if this actually happens. 2005 - 2023 WebMD LLC, an Internet Brands company. Select a condition to view a list of vitamins. However, the currently available evidence is preliminary in nature, so randomized controlled trials and large cohort studies are needed to confirm these findings. For those who supplement multiple times per day, it is recommended to keep the doses 4-6 hours apart from each other. Effect on plasma serotonin and histamine release and blood conservation. It is also a parasympathomimetic acetylcholine precursor [1] which has been investigated for its potential for the treatment of Alzheimer's disease [2] and other dementias. Alpha GPC is 40% Choline by weight. In one study, healthy men aged 18-39 saw immediate memory-recall gains. It's converted to -GPC through two different pathways: The Kennedy Pathway is the chained-together reactions that make up one of our most important mechanisms for regulating cell growth. A-GPC use also increased physical force, with peak bench press force being 14 percent greater compared to placebo. It is a well-tolerated cholinergic supplement when used within the recommended dosing range. Uridine Monophosphate: Studies at MIT revealed that Uridine synergises extremely well with the Choline b-vitamin the combination increases the production of neuron cell membranesand improves spatial awareness and selective attention. It is also prescribed to treat memory loss and cognition impairment related to stroke, traumatic brain injury, and dementia.[3], Though most research has focused on age-related memory loss, alpha GPCs memory benefits dont seem limited to the elderly. We hope you found our Alpha GPC review helpful. As for the Alpha GPC, most users typically take between 500 mg and 1 gram per day, depending on Piracetam dose schedule. Additional choline works to amplify the cognitive enhancement effects of nootropics such as Huperzine A, Phosphatidylserine, and Caffeine. Moreno MDM. Studies show that its also a neuroprotectant that helps maintain the biochemical balance of the brain. Alpha GPC has a shorter half-life versus CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). 1. I would definitely recommend this product to anyone looking for a cognitive boost. - daydreamr8. It's a non-prescription supplement that's widely available online and in stores. Uridine is one of 4 repeating units that make up RNA (Ribonucleic Acid). See our medical disclaimer. Alpha GPC is well known for its positive physical and mental effects, both when taken alone and in combination with other nootropics. [10] Moreover, a 2021 mouse study found that alpha-GPC supplementation promoted atherosclerosis. Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease., Lee, Minwoo et al. L-Alpha glycerylphosphorylcholine ( alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It appears to also support cellular membranes, and may help prevent cognitive decline. For this, youd need to take Uridine Monophosphate. While Alpha-GPC is generally safe, it can cause some side effects like headaches. [10] Moreover, a 2021 mouse study found that alpha-GPC supplementation promoted atherosclerosis.[11]. This function is at the heart of alpha GPCs nootropic properties. [9], A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. A 2021 study assessed the effects of alpha GPC on stroke risk over ten years. Brain-scans have shown that people with higher dopamine levels tend to be go-getters. L-Theanine: Review of Nootropic Benefits, Uses, & Side Effects, L-Tyrosine: Review of Nootropic Benefits, Uses, & Side Effects, Ginkgo Biloba: Review of Nootropic Benefits, Uses, & Side Effects, French Maritime Pine Bark Extract: Review of Nootropic Benefits, Uses, & Side, Rhodiola Rosea: Review of Nootropic Benefits, & Uses, Citicoline (Cognizin): Review of Nootropic Benefits & Uses, All Articles About Vitamins & Supplements, Best Legal Over the Counter Adderall Alternatives, How to Improve Cognitive Ability & Skills, Perfect for people who want to improve their cognitive function, Can help people with Alzheimer's disease and dementia, Not the ideal nootropic for people taking anticholinergics such as Scopolamine (Devil's Breath), Treating Alzheimer's disease and dementia, Improved memory and cognitive performance in elderly adults, Tamura, Yasuhisa et al. In Russia and some European countries, it is available as an oral or injectable prescription treatment for Alzheimers, sold under the brand names Gliatilin and Delecit and used to enhance memory, improve cognitive function, and help restore and maintain biochemical balance in the brain. Those using scopolamine are advised to consult a physician before taking alpha GPC. We prioritize reader needs over commercial interests and maintain editorial independence. You should study the effects and potential side effects carefully before adding any supplement into your routine, whether it be for brain function, brain health, or physical health. Fast Worldwide Shipping Made in the UK 300+ Verified Reviews All Cards and PayPal Accepted. This will help you choose the right product. Theres a good chance that if youre reading this Alpha GPC review, you already have some basic knowledge on choline. 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