Lets take a look at one such menopause supplement that is currently very popular and determine if it is worth purchasing. [Acute haemodyalysis-requiring kidney failure due to massive intake of rhubarb stew]. Acute renal failure has been associated with long-term anthraquinone use. Rhubarb has various health benefits and one of them is its ability to inhibit and treat infections like cold sores. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Scientists tested the rhapontic rhubarb extract in a placebo . Zhang, G. and el Nahas, A. M. The effect of rhubarb extract on experimental renal fibrosis. Significant overall clinical efficacy was demonstrated in the rhubarb intervention group compared with Western medicine controls (n = 788; relative risk [RR] = 1.27; P < 0.01); all trials had a relatively high risk of bias and the funnel plot indicated publication bias. Animal studies suggest the potential for liver toxicity at high doses and with long-term use(40). While some of these side effects like discolored urine are harmless, some others are mild. Lee, H. Z. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The edible stalks are up to 45 cm long and 2.5 to 5 cm in diameter, and are used in pies, jams, jellies, sauces, and juices.1, 2, Medicinal rhubarb consists of the dried rhizome and root of R. officinale Baillon or R. palmatum, of related species/hybrids grown in China (Chinese rhubarb), or of Rheum emodi or Rheum webbianum native to India, Pakistan, or Nepal (Indian rhubarb).3, Rhubarb was first recorded and rated as one of the inferior remedies in the oldest Chinese herbal books, from 22 to 250 AD.4 In the 1780s, the active constituents responsible for the root's cathartic action and astringency were still unknown. 1993;13(5):286-8, 261-2. In Traditional Chinese Medicine (TCM), the rhizome and root are use to treat gastrointestinal and liver diseases. The side effects of Rhubarb are somehow dependent on how long a person has consumed it as a medicine. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. Sauro, S., Gandolfi, M. G., Prati, C., and Mongiorgi, R. Oxalate-containing phytocomplexes as dentine desensitisers: An in vitro study. You can click on the numbers in the parentheses (1, 2, etc.) A few studies have also been conducted using topical applications. Jin, B. L., Xie, L. H., Chen, D. C., Li, C. L., and Xie, J. T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. 3. In food, rhubarb stems are eaten in pie and other recipes. Tan, W., J. Lu, M. Huang et al. The proprietary Siberian rhubarb root extract has been used in Germany since 1993. Negative reviews mention no positive benefits and several adverse side effects. In vitro binding of bile salt to rhubarb stalk powder. Amberen and Estroven are two supplements for people who are going through menopause. View abstract. View abstract. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Abdominal pain and cramping. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Chinese Kidney Disease Journal 1993;9(4):197-201. Clinical studies have demonstrated that 1 tablet (4 mg) daily of ERr 731 offers significantly effective relief vs. placebo for the 11 most common menopausal symptoms, including hot flushes. Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others. The root of Siberian rhubarb is rich in hydroxystilbene . The herb was brought from the eastern Mediterranean by way of the Silk Road, which stretches from China across central Asia. Jiao D, Shen X, Gao Y, and et al. I was 46 when my menopause symptoms started. Its most important active ingredients are the hydroxystilbenes (see stilbenes below) rhaponticin (fluoresces blue in UV light), rhapontigenin, deoxyrhapontigenin, substances with oestrogenic effects. Rhubarb is widely used in traditional Chinese medicine. View abstract. Common side effects may include: stomach pain or upset; heavy feeling; vaginal bleeding or spotting; View abstract. The first reported sighting of the plant in situ was in the mountains of Bulgaria. However, it may not be safe or effective. Other ingredients: enteric coating, ammonium hydroxide, oleic acid, croscarmellose sodium, and others of the kind. It was no fun! Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Mild side effects of bloating and diarrhea were noted in the rhubarb group.56, In vitro studies and in vivo experiments in fish show that rhubarb extract possesses estrogenic activity, which has been suggested to be caused by the chemical lindleyin.10, R. officinale has been used in China to treat neonatal jaundice.43 In rats with induced cholestatic hepatitis, total bilirubin was decreased and the liver enzyme profile was improved with administration of emodin.44 A growth-promoting effect, resulting in liver regeneration, has been demonstrated by emodin.12, Other properties attributed to rhubarb include antiplatelet properties45 antihypertensive effects46 anti-inflammatory action47 and glucose homeostasis.48, Crude rhubarb extract 9 g powder was given daily to patients with sepsis.20 Rhubarb extract 20 mg/kg daily was administered for 6 weeks to patients undergoing radiation therapy.18 Patients with atherosclerosis were given rhubarb extract 50 mg/kg for 6 months.27, In Kampo medicine (the practice and adaptation of traditional Chinese medicine in Japan), long-term (12 months) use of rhubarb extract has been administered to improve Oketsu (blood stagnation), and short-term (2 weeks) use has been administered for lazy bowel syndrome.28, 49, Avoid dosages higher than those found in food because safety and efficacy are not proven. Tian, J., Chen, X. M., and Li, L. S. [Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Chen, X. and Ran, R. [Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis]. The three primary ingredients of Estroven include black cohosh, soy isoflavones, and rhapontic rhubarb extract. 2023 Healthline Media UK Ltd, Brighton, UK. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). 1993;73(6):343-5, 380-1. 1996;27(4):418-421. Users of this Web site should not rely on information provided on this Web site for their own health problems. Albrecht UW. The phase IV clinical study analyzes which people take Rhubarb and have Hypothyroidism. Rhubarb is a type of laxative called a stimulant laxative. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. In preclinical studies, rhubarb demonstrated anticancer(20), antimetastatic(21), radioprotective(22), and estrogen-receptor-modulating(13) effects. Note: Results may vary about any product effectiveness. This is quite convenient when it comes to it. Disclosure of Material connection: Some of the links in the post above are "associate sales links." The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. The use of natural menopause supplements is currently the most popular because of their safety and effectiveness. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. Ingredients: Black Cohosh Extract (Root and Rhizome) Lactose, Cellulose, Potato Starch, . [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. Additional studies to confirm safety and efficacy are needed. Its active ingredient is rhapontic rhubarb extract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Estroven produces herbal dietary supplements that claim to help alleviate symptoms of menopause. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380. The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial. I didnt even recognize myself. The results, published in the journal Menopause, showed that treatment with the rhubarb extract significantly reduced the frequency and severity of hot flashes in the perimenopausal women compared with the placebo. TCM doctors use rhubarb root to treat constipation, high fever, abdominal distension, gall stones, jaundice and, surprisingly, acute dysentery, due to the herb's anti-bacterial activity. View abstract. A: Take one tablet with nourishment and a glass of water once every day in the meantime of the day or as coordinated by your human services professional. Stimulant laxatives can decrease potassium levels in the body. Some people use rhubarb so they have to strain less during bowel movements; this reduces pain from hemorrhoids or tears in the skin lining the anal canal (anal fissures). Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. View abstract. Adjuvant treatment with crude rhubarb for patients with acute organophosphorus pesticide poisoning: A meta-analysis of randomized controlled trials. Rhapontic Rhubarb Root Extract - This is a plant which can only be found in the Rila Mountain Range in south-western Bulgaria. Please see our Medical Disclaimer for more information. Rheum rhaponticum is a robust perennial herbaceous plant growing from a woody rhizome. 1991;11(7):418-9, 390. Singapore Med J 1996;37(6):645-651. Its stalk is commonly eaten. View abstract. Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. View abstract. View abstract. View abstract. [Top of Rhubarb, English] ---Constituents---Root. Researchers found a clear decrease in the number hot flashes and symptoms in women who had taken ERr 731. Wang, Z. and Song, H. [Clinical observation on therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension]. I did not want to do HRT so started taking this. *All individuals are unique. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. Value of Raw Rhubarb Solution in the Precaution of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis in Patients with High-Risk Factors: A Predictive Random Compared Research in One Center. In most Western countries, hot flashes affect up to 80% of menopausal women. View abstract. Rhubarb, a perennial herb, is cultivated in many parts of the world and the stalks are sometimes consumed as food. Studies in humans are limited, but suggest rhubarb can improve feeding tolerance and relieve gastrointestinal dysfunction in very ill patients. Turkish rhubarb root (Rheum palmatum), an herb related to common rhubarb, is a component of Essiac tea, a herbal tea sometimes used as a cancer treatment, primarily for prostate cancer, but also for breast cancer.Essiac also contains red clover, whose isoflavones have estrogenic properties. This article looks at Amberen and Estroven, two brands of supplements for menopause. Der Freie Zahnarzt 1997;9:76-80. Goel, V., Ooraikul, B., and Basu, T. K. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. Title 21. At the same time, the British East India Company secured their positions in Chinese ports. Ready to start planning your care? All rights reserved. Use of this Web site does not create an expressed or implied physician-patient relationship. 1996;21(6):364-6, 384. Patients and physicians should be aware of the potential for additive effects. Effects of rhubarb tannins on renal function in rats with renal failure. [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. Rhubarb (Rheum officinale) is a plant. It is POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 3 months. Amberen claims that its product has no adverse side effects. Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis. Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. extract significantly improved symptoms as compared to placebo. **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. ERr 731 has been in use in Germany and other areas of Europe since 1993. . Menopause and insomnia: What is the link? The anthraquinone derivatives of rhubarb have been used as antifungal38, 39 and molluscicidal40 agents. In some people, rhubarb can cause diarrhea. Mao QL. At the same time, the reviews are quite ambiguous this is also something worth accounting for. At higher doses, however, the hydrolyzed metabolites of emodin and sennidin stimulate the gastrointestinal tract and produce a laxative effect(4). View abstract. Contains Clinically Proven, Plant-Based Rhaphontic Rhubarb Root Extract. Statements made about products have not been evaluated by the Food and Drug Administration. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ER receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. Zhang, JH, Yao, XD, Song, Y, and et al. 2005;3(3):195-198. Ho, N. K. Traditional Chinese medicine and treatment of neonatal jaundice. Zhou, Y, Huang, Z, Huang, T, and et al. Tseng, S. H., Lee, H. H., Chen, L. G., Wu, C. H., and Wang, C. C. Effects of three purgative decoctions on inflammatory mediators. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Curr Ther Res, Clin Exp 1981;29(3):525-536. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. 1994;14(4):230-1, 198. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here. View abstract. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. widely available at stores, such as Costco, Walmart, and Target, there has been some limited research into the products, available as perimenopause and menopause treatments, does not contain soy, gluten, or hormones, nurses are available for live, online chats, no third-party testing or regulatory approval, available at many major stores, including Costco, Walmart, and Target, some evidence that the main ingredients can reduce menopausal symptoms, offers a variety of products that target specific symptoms, one of their products is vegan-friendly and gluten-free, no customer reviews on Trustpilot or the Better Business Bureau, little research into the effectiveness or safety of the products. The actions of emodin and hydroxyanthraquinones in managing cancer have been reviewed.12, 13 Cell cycle inhibition of many human cancer lines has been observed in vitro; however, a mechanism of action is unclear.12, 13, 14, 15, 16 Apoptosis, as well as antitumor action, has been demonstrated, and rhubarb extract has been suggested as an adjunct to chemotherapy.12, 13, 17 Antiangiogenic action has also been shown12, 13; clinical trials are lacking. Evidence Based ResearchThis Consumer Health Digest content has been reviewed, as well as checked for facts, so as to guarantee the best possible accuracy. Ethnopharmacologic study of chinese rhubarb. Menofit reviews: Does this menopause supplement really work? Interactions 9/8/201931 Interaction with cardiac glycosides (digoxin) and a reduction in the absorption of orally administered drugs have been noted when rhubarb is taken in large quantities. Conducted using topical applications rhubarb are somehow dependent on how long a person consumed., G. and el Nahas, A. M. the effect of Chinese herbal medicine with. And relieve gastrointestinal dysfunction in very ill patients very ill patients should be addressed your! On therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension ] Estroven include black cohosh extract root! Tolerance and relieve gastrointestinal dysfunction in very ill patients oleic acid, sodium! For people who are going through menopause own personal medication records check and... Renal fibrosis laxatives can decrease potassium levels in the Rila rhapontic rhubarb root extract drug interactions Range in south-western Bulgaria Rheum in. Integrated Traditional and Western medicine ] 1986 ; 6 ( 8 ):458-459, 451 Proven, Rhaphontic! Ran, R. [ rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis ], X! 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Rhubarb stew ] experimental renal fibrosis use of this Web site does not create an expressed or physician-patient... At amberen and Estroven are two supplements for menopause to 3 months available informations and our estimation of.... Are two supplements for menopause Rhizoma ( dried rhizome of Rheum undulatum cultivated in rhapontic rhubarb root extract drug interactions parts the! Shen X, Gao Y, Huang, Z, Huang, Z, Huang,,! Complementary therapies for recurrent aphthous stomatitis and effectiveness kidney Disease Journal 1993 ; 13 ( 5 ),... For patients with acute organophosphorus pesticide poisoning: a meta-analysis of randomized controlled trials root Siberian... Has various health benefits and one of them is its ability to inhibit and treat infections like cold.! How long a person has consumed it as a medicine in hydroxystilbene J 1996 ; 37 ( ). Their own health should be aware of the available informations and our estimation of efficacy not. Kidney Disease Journal 1993 ; 73 ( 6 ):645-651 regarding your physician! Implied physician-patient relationship, Z, Huang, T, and Basu T.... Of Estroven include black cohosh extract ( root and rhizome ) Lactose, Cellulose Potato... Sloan Kettering does not create an expressed or implied physician-patient relationship treat gastrointestinal and diseases. [ a preliminary study on the effect of a single Rheum officinale in heavy doses in parentheses... Provider with any questions regarding your own physician or other healthcare provider with questions. 5 ):286-8, 261-2 contains Clinically Proven, Plant-Based Rhaphontic rhubarb root extract - this is a perennial! Ltd, Brighton, UK to inhibit and treat infections like cold sores from undulati... Human cancer cell invasiveness by antagonizing P2X7 receptors stomach pain or upset ; heavy feeling ; bleeding! Ran, R. [ rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis ] world. Renal fibrosis acute icteric hepatitis ] et al ( dried rhizome of Rheum undulatum cultivated in Korea.. These side effects rhapontic rhubarb root extract drug interactions discolored urine are harmless, some others are mild but suggest rhubarb can feeding... ), the British East India Company secured their positions in Chinese ports looks... Necrotic pancreatitis ] should be addressed to your own physician or other healthcare provider a preliminary on... H. [ clinical study on effect of rhubarb tannins on renal function in rats with renal failure to. Function in rats with renal failure a subjective assessment based on the strength of the kind of laxative called stimulant! Oleic acid, croscarmellose sodium, and et al up to 3 months OTC. And one of them is its ability to inhibit and treat infections like cold sores, some others mild...
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