According to Nasdaq data, in the past 3 months there has been one open market purchase of MRNA shares by an insider amounting to 50,010 shares and there have been 76 insider sales amounting to 12,188,398 shares. Before that, the funds also sold 1 million shares for $68.2 million (pretax) in May 2020. Flagship Pioneering Noubar. We find heroes that are helping people. Its about brilliant people, all of them migrs, some Jewish, whose vaccines will hopefully save countless lives in Israel and the world. He is best known for co-founding the biotechnology company Moderna, through his venture capital firm, Flagship Pioneering, and for co-founding humanitarian projects such as Aurora Prize and The Future Armenian. Here are his responses to my questions. After college at McGill University, where he studied chemical engineering, Afeyan completed a Ph.D. in biochemical engineering at MIT in 1987. How does one describe someone who has helped found 38 companies? Flagship Pioneering. ahin is the CEO and cofounder of BioNTech, which he started alongside his wife and chief medical officer zlem Treci. "[2] According to the company website, Flagship Pioneering has "fostered the development of more than 100 scientific ventures resulting in $30 billion in aggregate value, thousands of patents and patent applications, and more than 50 drugs in clinical development. Among them: Karl Landsteiner, whose research enabled physicians to transfuse blood without endangering patients lives; Paul Erlich, pioneer of chemotherapy, who found a cure for syphilis; Magnus Hershfield, among the earliest advocates for homosexual and transgender rights; and my favorite, Rosalind Franklin, whose X-ray diffraction images of DNA at Kings College, London, led Crick and Watson to their pathbreaking discovery of the DNA double helix. Had she lived, she should surely have shared the DNA Nobel. Afeyan was born in Beirut and his family later moved to Montreal, Canada. Flagship currently holds 20.5 million shares of Moderna worth $6.6 billion after selling off $3.4 billion according to their SEC Filing 13-F. How is it possible that there are all these beneficial microbes and not any beneficial viruses? Afeyan asks. Even though it was the governments policy of carrying this out, the actual officers were revolted by seeing train loads of people being taken to their deaths.. A new study shows immigrants produce a significant percentage of innovations in America and make U.S. natives more inventive. Afeyan describes the process as Darwinian. Noubar Afeyan launched 70 companies by pushing researchers to ask what if their craziest ideas were true. Langer is a chemical engineer and professor at the Massachusetts Institute of Technology, where he leads the eponymous Langer Lab; he owns a 3% stake in Moderna, which he helped start in 2010. . Afeyan also spoke at length about the Aurora Humanitarian Initiative that he, Gregorian and Russian-Armenian entrepreneur Dr. Ruben Vardanyan had founded four years ago, and its mission to express gratitude for the help Armenians received in their darkest hours. Have you wondered how to push the limits of your imagination in your research to drive significant and impactful change? Afeyan, whose family moved to Canada as political refugees during the 1975 civil war in Lebanon, came to the US to earn his PhD in biochemical engineering from Massachusetts Institute of Technology. At the time Moderna spun out from Flagship ten years ago, Flagship held roughly 60 million shares, and since 2019 it has periodically made distributions of roughly half that sum to its investors. Flagship funds retain 20 million shares in Moderna after the transactions. He calls his model parallel entrepreneurship, meaning he wants to found multiple companies at a time, not just one or two, but six or eight. If the idea proves promising enough, Flagship invests, and it operates for a time as a wholly owned subsidiary. He did his undergraduate work at McGill University and completed his PhD in biochemical engineering in MIT. Noubar Afeyan Senior Managing Partner and CEO of Flagship Ventures. Noubar invented the model, if you will, and essentially trained us in doing this.. Repertoire is working to understand the inner workings of the immune system. Noubar Afeyan, chairman and co-founder of Moderna, joins Fareed to talk about the new Omicron coronavirus variant. We need to leverage what we have gone through to help other people, he said. Pfizers CEO is Albert Bourla. Noubar Afeyan at the NAASR virtual gala. The shares were sold at an average price of $139.00, for a transaction totalling $1,390,000.00. It was another to make it a process, Afeyan says. I think of it as chess. This is a BETA experience. Other pharma executives have been selling shares as well, but not to the extent of those at Moderna. I cover the world's richest people and how they made their billions. He was living a similar life to what I live now. It was only days after Pfizer announced clinical trials showed the vaccine was 90% effective at preventing COVID-19. Flagship Pioneering, a VC fund run and majority owned by Moderna chairman and cofounder Noubar Afeyan, sold $1.4 billion of shares in late February and late March. life sciences innovation firm Flagship Pioneering. There is really no word to describe what he is. Hes very provocative and very challenging and very demanding, says Simba Gill, CEO of Evelo Biosciences, a Flagship company focused on the microbiome, who first met Afeyan more than two decades ago. This past April, for example, Ohana Biosciences, a fertility company that focused on sperm-based treatments, shut its doors and laid off most of its staff a little over a year after emerging from stealth. Shares in companies producing vaccines, antibodies and other tools to combat the Covid-19 pandemic have skyrocketed since March 2020. With $17 billion and a model of "parallel entrepreneurship," he can fund a lot of wild. Executives at Moderna and other pharma companies that developed vaccines for Covid-19, including Pfizer and Novavax, sold a further $400 million in shares over the same time period, for a total of $1.9 billion. in the wake of domestic violence allegations by his then-wife. Noubar Afeyan (Western Armenian: ; born in 1962) is an American-Canadian entrepreneur, inventor, and philanthropist. The new proteins "could provide countless new intervention points across diseases," Noubar Afeyan, founder and chief executive of Flagship, said in a statement. Afeyan is Armenian, emigrated from Lebanon to Canada and eventually did his doctorate at MIT. More than a few of those in the book, Lebrecht notes, fit this elusive category men and women who find the strength, in a time of crisis, to forge new paths in superhuman ways, with incredible genius for action and invention. He starts with those what-if questions. There is a very low probability in the biotech industry that any one product will work, so why subject millions of dollars and years of life in one binary product?, he says. As Flagships researchers studied the issue, he says, they learned of a family of viruses, known as anelloviruses, that live in humans but had been largely dismissed because they werent harmful. An investor today will believe the vaccine. Noubar Afeyan launched 70 companies by pushing researchers to ask what if their craziest ideas were true. My son is a doctor, my mother would say but not the kind that helps people. Noubar Afeyan fully understood those risks when he co-founded Moderna in 2010. What keeps you from innovating is being comfortable. He praised the park on three levels: It is a beautiful public space, a park rich in symbolism and a place that celebrates the immigrant experience. I cant resist giving a plug to the Jewish mother theory of genius, by the legendary Israeli entrepreneur and angel investor Yossi Vardi. Founded in 2000, Flagship is an enterprise where entrepreneurially-minded scientists invent seemingly unreasonable solutions to challenges facing human health and sustainability. He was born, raised and educated in Thessaloniki, in northern Greece. Noubar Afeyan is a serial entrepreneur Afeyan has made a career out of being a co-founder. They do, indeed; I had one. His wife, Brenda, who studied at Harvard's Divinity School, recently launched a second foundation called Champions of Love. Miller is the founder and executive chairman of healthcare services provider Universal Health Services, which conducts testing for Covid-19 and treats patients at its network of hospitals across the U.S. Cao Xiaochun is the cofounder and director of pharmaceutical contract research outfit Hangzhou Tigermed Consulting, which supported clinical trials for CanSinos Covid-19 vaccine. Noubar Afeyan . Two Flagship fundsFlagship Ventures Fund IV, L.P. and Flagship Ventures Fund IV-Rx, L.P.sold 53% of their Moderna holdings, about 10.3 million shares, for more than $1.4 billion (pretax) in three sets of sales in late February and late March this year. Gregorian is the former president of Brown University as well as the NewYork Public Library. He spent his childhood in Beirut until August 1975, when he fled the civil war with his parents and two older brothers at age 13, this time arriving in Canada. The program also was a fundraiser for the maintenance of Bostons Armenian Heritage Park on the Greenway and it did not disappoint; the roughly 500 people gathered there raised $700,000. And that's . I was literally mesmerized. Afeyan says, I started to learn everything I could about how to start companies., If you play parallel chess, you have got to get to the essence. [1] He has patented over 100 inventions. In 2000, Afeyan founded Flagship Pioneering to create and fund early-stage start-ups addressing unmet needs in healthcare and sustainability. ( 25, 1962 [1], , ), , Flagship Ventures [2] . Noubar was born in Beirut to Armenian parents in 1962, did his undergraduate work at McGill University in Montreal, and completed his Ph.D. in biochemical engineering at MIT in 1987. The unprecedented boom in healthcare stocks helped mint at least 40 new billionaires with ties to companies fighting Covid-19. The only criticism I have faced on this score has been from some Israeli interviewers who wanted to know why I regard Jews who converted as remaining part of the Jewish cultural unconscious. Afeyan is a lecturer at Harvard Business School and also taught at MIT's Sloan School of Management from 2000 to 2016. Yu De-Chao is the founder and chairman of Chinese biopharma outfit Innovent Biologics, which is developing a potential antibody treatment for Covid-19. The company signed a deal with British pharma titan AstraZeneca in August to make at least 100 million doses of its Covid-19 vaccine. As I write this, the world has just entered its third . Why Are Moderna Insiders Selling So Many Shares? That massive rise, of over 300% has also helped the three men behind the firm. As of November 2021, his net worth is estimated at $3.3 billion. LEBRECH RECOUNDS the genius of such well-known figures as Marx, Freud, Einstein and Kafka. Afeyan had partnered with Vardanyan to establish Initiatives for Development of Armenia (IDeA),[23] which according to the Armenian government, has between 2007 and 2017 implemented different projects with a total cost of $550 million. Modernas fifth-largest individual shareholder, president Stephen Hoge, sold $65.5 million worth of Moderna stock since March 2020; Hoges 0.4% stake in Moderna is worth roughly $300 million, but he also owns about $545 million in options. Fareed sits down with Noubar Afeyan to break down the revolutionary mRNA technology that underpins both Pfizer and Moderna's Covid-19 vaccines. As the firms researchers explore ideas, theyll change their approachor even what theyre working onwith little regard for how the outside world might view such seeming flip-flops. Dec 14, 2020, 8:59 AM. Others got rich making everything from personal protective equipment and diagnostic tests to antibody treatments and software that helps authorities schedule vaccination campaigns, which will be essential in reopening economies and returning to normal life. He called the park as a community partner for the city, one which gives an arena to immigrants to tell their stories.. Over time, Afeyan set up a structure for brainstorming new companies. Between 2000 and 2005 the firm produced an average of two companies a year. (Each year the two halves of the sculpture are pried apart and reconfigured in a new way, to symbolize leaving the past and creating a new life. degree at Ben-Gurion University of the Negev. Flagship relies on a handful of internal teams, such as one led by longtime biotech executive John Mendlein, to investigate ideas and launch companies in particular areas. Bancel knew he needed to reach out to Moderna cofounder Noubar Afeyan, the serial biotech entrepreneur who runs Flagship Pioneering in Cambridge and chairs Moderna's board of directors. At the conclusion of the event, Afeyan said, I am happy that the occasion brought this many people out to support the Armenian Heritage Park.. He's also the chairman and cofounder of biotech firm Moderna, known for its Covid-19 vaccine which was authorized by the U.S. FDA in December 2020. Pfizer CEO Albert Bourla sold about 60% of his stake in the company under a preset sale plan in November for about $5.6 million (pretax). He and his wife Veronika invest in large-scale multifaceted projects in the sphere of global education, Sustainable . He has been working on revamping the business and scrapped a strategy of selling directly to farmers in favor of partnerships with agricultural distributors. In both, I dealt with specifically Jewish aspects of his life and work that had not been treated before. [24] Earlier, in 2001 Afeyan, Vardanyan and others launched the "Armenia 2020" initiative, which aimed to identify development prospects for Armenia until 2020. Afeyan wondered if a safe virus could replace the existing viruses in that role. Together with his partners, he has launched philanthropic projects including the Aurora Humanitarian Initiative, FAST Foundation, and the UWC Dilijan School. Photo by Jake Belcher. The firm has "fostered the development of more than 100 scientific ventures, resulting in $20 billion in total value and over 500 patents. He was born to Armenian parents in Lebanon and immigrated with his family in his early teens to Canada. Photograph by Jared Charney Don't call Noubar Afeyan a venture capitalist. NET WORTH: $1.9 BILLION SOURCE OF WEALTH: BIOTECH Highly Skilled Immigrants Drive U.S. A screenshot of Moderna's stock price over the . [1][15][2], In July 2022, Afeyan was conferred with a honorary doctorate degree from Yerevan State University. [15][2], Afeyan has worked closely with other prominent Armenian diaspora philanthropists, most notably Ruben Vardanyan on projects related to Armenia. According to SEC filings, Afeyan owns at least 75% of Flagship, and the firm directly owns 4% of Flagship Ventures Fund IV but doesnt own any of Flagship Ventures Fund IV-Rx. As Moderna shares plunge below $50 in Wednesday morning trading, I called back to my Forbes article of last week. Deval Patrick and an official delegation from Armenia. Schuler is the former president of healthcare multinational Abbott Labs and the owner of a 7% stake in diagnostic firm Quidel Corp., which was one of the first companies to receive FDA approval for its Covid-19 tests in March 2020. Following the completion of the sale, the director now directly owns 2,187,209 shares of the company's stock, valued at $304,022,051. [1][2] He is best known for co-founding the biotechnology company Moderna, through his venture capital firm, Flagship Pioneering, and for co-founding humanitarian projects such as Aurora Prize and The Future Armenian. Noubar Afeyan. He is a Senior Lecturer at the MIT Sloan School of Management. Noubar Afeyan has cofounded more than 35 successful life sciences and technology start-ups, but likely none more impactful than Moderna, Inc., which last year came up with the first mRNA-1273 COVID-19 vaccine, now protecting millions around the world from the pandemic virus. 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There he oversaw the creation of Celera Genomics. Co-Chair, Noubar & Anna Afeyan Foundation Anna Afeyan Gunnarson has been involved in educational non-profit work for the past 20 years as a volunteer, teacher, board member and philanthropist through the Noubar and Anna Afeyan Foundation. Oyler is the CEO and cofounder of Beijing-based drugmaker BeiGene, which signed an agreement with biotech outfit Singlomics Pharmaceuticals in August to develop, manufacture and sell Singlomics antibody treatment for Covid-19. Afeyan, of Lexington, checked in tied for 1,804th. That is a huge, huge advantage. Hes also an investor in privately owned Inspirotec, which is developing technology to identify the presence of Covid-19 in the air. [34], In October 2016 Afeyan joined other prominent Armenians on calling the government of Armenia to adopt "new development strategies based on inclusiveness and collective action" and to create "an opportunity for the Armenian world to pivot toward a future of prosperity, to transform the post-Soviet Armenian Republic into a vibrant, modern, secure, peaceful and progressive homeland for a global nation. Forbes estimates Springer has a net worth of $2.6 billion while Langers is $2.1 billion. And that reckless zone is Afeyans sweet spot because thats where the big breakthroughs will happen. His grandfather escaped to Bulgaria, where his father was born. I am concerned here only with this specific period, 1847-1947, which was also the period of greatest creativity in human history. As its assets have grown the pace at which Flagship has founded startups has accelerated. Noubar Afeyan, co-founder and chairman of Moderna, is a two-time immigrant. Later reports raised its effectiveness to 95%. Afeyan is leveraging that success to raise boatloads of new cash. All Rights Reserved. Noubar Afeyan, Co-Founder and Chairman of Moderna and Founder and CEO of Flagship Pioneering, champions proactive thinking and creating the right environment for new idea generation to innovate in leaps and bounds. On Friday, November 13, Prime Minister Benjamin Netanyahu signed a deal with the giant US pharmaceutical company Pfizer to purchase millions of coronavirus vaccine doses. The representatives, when singled out, received thunderous applause. He is also the founder of a company called PerSeptive Biosystems. Why the Jews played such a large role is rooted in a collective cultural unconscious - a common way of thinking - allied to a constant fear of disruption, as I explain in the book. He received the Golden Door Award in 2017 from the International Institute of New England in recognition of his contribution to the US as a foreign-born American. Afeyan added his praise to the organizations that were recognized for their work and especially the timing of the recognition at a time they are very much needed., I congratulate them and thank them for being here, he said. While scientists had talked about the microbiome for years, when Afeyan first broached the idea in 2008 of exploring its role in disease, including autoimmune diseases and cancer, it was pretty far out on the fringe. Boston is a city built by immigrants. Franklin was only 37 when she died of ovarian cancer; the many X-rays she absorbed in her lab may have been a factor. (Baker and Walsh, as well as Middlesex County Sheriff Peter Koutoujian were honorary chairs of the banquet.). They said, How can anyone give you money? The vaccine was developed two days after [publication of the coronaviruss genomic] sequence. [1], Afeyan sits on the boards of the MIT Corporation, the Boston Symphony Orchestra,[21][22][15] and the Armenian General Benevolent Union (AGBU). If you can understand why T-cells cause lesions in the brain that cause multiple sclerosis, you could design the right immune medicines to treat the disease rather than just damping down the immune response.. He has been a Senior Lecturer at MIT's Sloan School of Management where he has taught courses on technology . [3][1][14] Between 2000 and 2016 he was a senior lecturer at the MIT Sloan School of Management and is currently (as of 2020) a lecturer at Harvard Business School. Buoyed by Moderna, Flagships fourth fund, launched in 2012, topped a list of 17 high-performing biotech firms and was on track to return investors money 15-fold, according to research published by Stat in August. Cambridge, MA. Ideas that surviveas a total of 89 haveget numbers rather than names to keep founders from falling in love with a pet project that may need to be killed. Flagship has developed more than 100 scientific ventures resulting in over $100 billion in aggregate value, thousands of patents and patent applications, and more than 50 drugs in clinical development. Noubar Afeyan is founder, Senior Managing Partner and CEO of Flagship Ventures, a leading early stage venture capital firm. Exactly a year later, it is now worth $302.42. As of November 2021, his net worth is . He and his wife Veronika invest in large-scale multifaceted projects in the sphere of global education, Sustainable . Without the pandemic, Afeyan says, putting his hand on his head, we probably would not be as hellbent on doing it as we are now., Every one of our companies is born to aspire to what Moderna has done. It is also building out a new division focused on preemptive medicine, a more personalized, predictive type of preventive health care, as well as health security to better prepare for future threats from infectious diseases. 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