* A pair of clinical studies7 also found that astaxanthin can improve the appearance of age spots, wrinkles, and skin elasticity in both men and women. Jyonouchi H, Sun S, Iijima K, Gross MD. A review of astaxanthin suggests that it may have a negative impact on adaptations to exercise. Thanks to its increasing popularity, you can easily find astaxanthin supplements at most pharmacies and health food stores. Astaxanthin (3,3'-dihydroxy-,'-carotene-4,4'-dione) is a nonprovitamin A carotenoid classified as a xanthophyll and is found in high amounts in the red pigment of crustacean shells (e.g., crabs, shrimp), salmon, trout, and asteroides. Cell Biol Toxicol. Lyons, N. M. and O'Brien, N. M. Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture. Manabe, E., Handa, O., Naito, Y., Mizushima, K., Akagiri, S., Adachi, S., Takagi, T., Kokura, S., Maoka, T., and Yoshikawa, T. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. In women and those with vaginas, it helps prepare the uterus for pregnancy and plays a major role in healthy menstrual cycles and fertility. Supplement ingredients that are absorbed by the digestive system must pass through your liver. After all, reducing oxidative stress allows many parts of the body to function more efficiently. Zhang, X., Zhao, W. E., Hu, L., Zhao, L., and Huang, J. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARgamma) in K562 cancer cells. Espaillat A, Aiello LP, Arrig PG, et al. Nutrients 2021;13(12):4381. View abstract. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. View abstract. Kuhn R, Sorensen NA The coloring matters of the lobster (Astacus gammarus L.). J.Med.Food 2003;6(1):51-56. View abstract. Astaxanthin is a carotenoid, a chemical found naturally in certain plants and animals. J Nutr 2005;135(11):2507-2511. When it comes to antioxidant supplements, nutrients like vitamin C and vitamin E often steal the show. Djordjevic B, et al. A single-blind clinical investigation. A type of algae makes astaxanthin. View abstract. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. She has a Master of Science in Nutrition from Texas Woman's University and Bachelor of Science in Dietetics from SUNY Oneonta. View abstract. No Pills Required: Superfoods That Can Help Women Improve Their Sex Drive, What Supplements can Help Ease Your PMS Symptoms? This could have far-reaching benefits and may even reduce the risk of certain types of chronic disease. A plant? highest oxygen radical absorbance capacity. Brain Res 11-11-2010;1360:159-167. The supplement may react negatively with the hormone-altering medications if you are taking one. As a result, it could keep testosterone from changing into the hormone DHT in the body. * Astaxanthin can also enter the layers of cell membranes, ultimately helping to protect the cell from oxidative stress.*. J Assist Reprod Genet 2022;39(4):995-1008. Andersen LP, Holck S, Kupcinskas L, et al. Coconut oil, avocados, walnuts and beets are just a few examples of other brain foods that boost focus and memory. These conditions can cause a wide array of symptoms, ranging from blurry vision to complete vision loss. View abstract. Its actually none of the above! It can also be found in supplement form and is also approved for use as a food coloring in animal and fish feed. 2015;54(2):301-7. Jyonouchi H, Sun S, Tomita Y, et al. 2000;48:1150-4.. View abstract. Sports Med. 2012;52(4):382-392. Brain Res 2-13-2009;1254:18-27. One animal study published in the journalBiological & Pharmaceutical Bulletin, for instance,found that astaxanthin supplementation improved swimming endurance in mice. Astaxanthin is a carotenoid and very high intakes of carotenoids can cause your skin to turn orange. The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome. Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. Studies show that it can both improve the overall appearance of skin and may also be able to treat certain skin conditions. You know how the pigment beta-carotene makes carrots orange? Primary ingredients like vitamin E have shown improvements in correcting oxidative stress, or an imbalance between free. Arch Ophthalmol 2008;126(10):1396-1403. J Dermatol Sci 1998;16:226-230.. View abstract. Antimicrob.Agents Chemother. View abstract. Astaxanthin, or any antioxidant, can help fight against this stress. Minimizing your stress levels, getting in plenty of physical activity and cutting out ultra-processed foods are also key factors to keep your heart in tip-top shape. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Eye problems like macular degeneration and cataracts are common concerns associated with aging. J Sports Med Phys Fitness. Note that the numbers in parentheses (1, 2, etc.) Z Angew Chem 1938; 51: 465-466. Nutrients. * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health . Many people think of lutein as "the eye vitamin." Lutein is one of two major carotenoids . Were not talking about detox fads, but the process of detoxification that your body must do to stay healthy. Dietary beta-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice. WebMD does not provide medical advice, diagnosis or treatment. This is because it can protect cells from oxidative stress (are you seeing a pattern here?). Studies have demonstrated that astaxanthin is a natural antioxidant product and it is widely used in the fields of medicine, health-care products and cosmetics. Mahmoud, F. F., Haines, D. D., Abul, H. T., Abal, A. T., Onadeko, B. O., and Wise, J. Chen JT, Kotani K. Astaxanthin as a potential protector of liver function: a review. This can reduce hair loss and sometimes promote hair regrowth. We work with one of the few suppliers in the Natural Algae Astaxanthin Association, who set the standard for astaxanthin quality. Is It (Finally) Time to Stop Calling COVID a Pandemic? An animal? But again, this would only be at excessive doses. Nihon Ganka Gakkai Zasshi 2009;113(3):403-422. Urakaze M, Kobashi C, Satou Y, et al. By boosting T3 and T4 thyroid hormone levels, ashwagandha may play a role in managing hypothyroidism but worsen symptoms of hyperthyroidism. View abstract. *, Astaxanthin, like other carotenoids, can contribute to healthy peepers. However, the synthetic astaxanthin may not be quite as stellar for your health. pii: E817. View abstract. Future.Cardiol 2009;5(4):333-342. Metabolism, nutrition, and function of carotenoids. J Photochem.Photobiol.B 12-1-2006;85(3):205-215. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. But as always, we recommend checking with your doctor before taking a supplement, astaxanthin or otherwise. View abstract. Our online classes and training programs allow you to learn from experts from anywhere in the world. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on rheumatoid arthritis. Yuan, J. P., Peng, J., Yin, K., and Wang, J. H. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Wang, H. Q., Sun, X. As one of the most potent carotenoids and antioxidants found in nature, astaxanthin benefits many aspects of health, from diminishing wrinkles to upgrading your workout routine. What Vitamins and Supplements Can Help you Address a Hormonal Imbalance? Weve already discussed that astaxanthin is likely safe and has few side effects when taken as directed. Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial. As you get older, the risk of developing neurodegenerative disorders like Alzheimers or Parkinsons disease continues to increase. It does not appear to have a negative impact on the liver, kidney, or hormone health. A good amount of emerging research has found thatastaxanthin benefits brain health by preserving cognitive function. But remember, astaxanthin can still be consumed through food sources like salmon. Kirsten specializes in nutrition, fitness, food, and DIY; her work has been featured in a variety of publications, including eHow, SparkPeople, and international editions of Cosmopolitan. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. View abstract. When we exercise, the body is put under stress and has to adapt. Earnest CP, Lupo M, White KM, Church TS. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. Nutr Rev 1999;57:1-10. Effect of antioxidants on the immune response of Helicobacter pylori. Liu, X. and Osawa, T. Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food. Of course, a healthy diet containing astaxanthin is just one piece of the puzzle. This ad is displayed using third party content and we do not control its accessibility features. Often dubbed the king of carotenoids, research shows that astaxanthin is one of the most powerful antioxidants in nature. Astaxanthin is also responsible for the iconic reddish-orange color of marine animals like salmon and shrimp2, who receive the phytonutrient from the algae they consume. Belcaro G, Cesarone MR, Cornelli U, et al. Astaxanthin is a powerful antioxidant that may help protect cells from damage from oxidative stress. 2020;67(3):307-316. * Here's how that shakes out in published science: According to a 2021 scientific review, as astaxanthin exerts antioxidant effects, it may also help promote healthy blood pressure8. That means it helps reduce a natural process in your body called oxidation. It has been used safely in combination with other carotenoids, vitamins, and minerals at 4 mg daily for up to 12 months. Is astaxanthin good for inflammation? At this point, you may be wondering: How much astaxanthin should I take?. Studies show that it may have multiple beneficial effects when it comes to upping exercise performance and preventing injury. Astaxanthin side effects hormones Some laboratory studies have shown astaxanthin may hinder an enzyme called 5-alpha-reductase. Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., and Kondo, K. Inhibition of low-density lipoprotein oxidation by astaxanthin. Biosci.Biotechnol.Biochem 2007;71(4):893-899. Astaxanthin is no exception a randomized, controlled trial published in 2012, involving 96 subjects, reported a significant improvement in cognition after being supplemented with the antioxidant for 12 weeks. Astaxanthin | Perry Krichmar, MD Additionally, antioxidants like astaxanthin could protect the brain by neutralizing oxidative stress. It's also available in natural supplement form. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Fassett, R. G., Healy, H., Driver, R., Robertson, I. K., Geraghty, D. P., Sharman, J. E., and Coombes, J. S. Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial. Inflammation is an important part of the bodys immune response. Kishimoto, Y., Tani, M., Uto-Kondo, H., Iizuka, M., Saita, E., Sone, H., Kurata, H., and Kondo, K. Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. View abstract. To maximize the absorption and health benefits of astaxanthin, its best to get your daily dose by incorporating whole food sources into your diet. Information from this source is evidence-based and objective, and without commercial influence. Care/ofs astaxanthin supplement provides 6mg per serving of natural astaxanthin, which a review study reported no adverse effects at this daily dosage level and up to 12mg or more per day. Fletcher, A. E., Bentham, G. C., Agnew, M., Young, I. S., Augood, C., Chakravarthy, U., de Jong, P. T., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J. R., and Vioque, J. Sunlight exposure, antioxidants, and age-related macular degeneration. This makes it difficult to set a standard dose. View abstract. However, the recommended dosage can vary by country and has been found to range between 2 and 24 mg per day. Click here to find out. Eur.J.Pharm.Sci. The other protects the water-soluble part of cells. Research shows that it may be able to help improve brain, skin and heart health, support better vision, boost male fertility, increase endurance and reduce inflammation. The two major female reproductive hormones are estrogen and progesterone. A review published in GeroSciencealso noted that the neuroprotective properties of astaxanthin may be due to its ability to reduce oxidative stress and inflammation. View abstract. are clickable links to these studies. Am J Cardiol 5-22-2008;101(10A):20D-29D. Ikeuchi, M., Koyama, T., Takahashi, J., and Yazawa, K. Effects of astaxanthin in obese mice fed a high-fat diet. Nakagawa, K., Kiko, T., Miyazawa, T., Carpentero, Burdeos G., Kimura, F., Satoh, A., and Miyazawa, T. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Supplement makers may suggest varying amounts of astaxanthin for different purposes. J Cell Biochem 4-15-2008;103(6):1925-1937. A later study in 2016 also on competitive male cyclists gave evidence to astaxanthins performance-enhancing effect. Chronic inflammation, on the other hand, can contribute to conditions like diabetes, cancer and heart disease. View abstract. View abstract. A., Glamm, J. E., and Failla, M. L. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. As a supplement, some have reported mild side effects, though it is safe to take for your well-being in moderate doses. Not only is wild salmon naturally higher in this important carotenoid, but its also been shown to be safer for consumption and contain fewer contaminants. Anderson, M. L. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. In fact, astaxanthin may help support the health of these body systems. View abstract. Having a healthy level of progesterone is mostly beneficial, no matter who you are. Kirsten Nunez is a health and lifestyle journalist based in Beacon, New York. Avoid taking astaxanthin if you're allergic or sensitive to it. Peng, C. H., Chang, C. H., Peng, R. Y., and Chyau, C. C. Improved membrane transport of astaxanthine by liposomal encapsulation. Astaxanthin is a red pigment. View abstract. OTHER NAME(S): Astaxanthine, Astaxantina, Dihydroxy-3,3 dioxo-4, Astaxanthin has most often been used by adults in doses of 4-18 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. These foods are especially beneficial because most provide an array of important nutrients in addition to astaxanthin, such as vitamins, minerals and omega-3 fatty acids. Other potential side effects include increased skin pigmentation (astaxanthin is the compound that gives flamingos, salmon, and shrimp their pink color) and hair growth, hormonal changes, lowered blood levels of calcium, decreased libido, breast enlargement in men, and changes in blood tests. Note that astaxanthin is only included in the Women's Balance supplement. Astaxanthin is a carotenoid, like beta-carotene. Briviba, K., Bornemann, R., and Lemmer, U. Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy. View abstract. View abstract. Bennedsen M, Wang X, Willen R, et al. View abstract. View abstract. View abstract. Should You Take A Collagen Supplement? Health Conditions Featured Breast Cancer IBD Migraine Multiple Sclerosis (MS) Rheumatoid Arthritis Type 2 Diabetes Sponsored Topics Articles. We know that carotenoids are antioxidants and may have certain health benefits. Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases. *, Carotenoids in general are associated with heart health, and astaxanthin is no exception. Note not all astaxanthin is biosynthesized by living microalgae. More research is needed to better understand astaxanthin's effects on hormones. Bioorg.Med Chem Lett 8-2-2004;14(15):3985-3991. BMC.Nephrol. View abstract. View abstract. According to a 2018 comprehensive review article, it comes down to its molecular structure. View abstract. Asia Pac J Clin Nutr. View abstract. View abstract. It can also be found in some other supplements, such as krill oil, some omega-3 formulations and Arctic Ruby Oil. J Herb Pharmacother 2005;5(1):17-26. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., and Nishigaki, Y. Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells. Blind, randomized trial also be found in some other supplements, nutrients like vitamin have. And beets are just a few examples of other brain foods that boost focus memory. Living microalgae is a carotenoid, a healthy level of progesterone is mostly beneficial no. 6 ):1925-1937 85 ( 3 ):205-215 it does not provide advice. Provide medical advice, diagnosis or treatment are absorbed by the naturally occurring carotenoid astaxanthin astaxanthin still... Shopping when you have Diabetes, cancer and heart disease Association, who set the standard for quality. 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Of progesterone is mostly beneficial, no matter who you are most pharmacies and health food stores one... Clinical trial research is needed to better understand astaxanthin 's effects on hormones as & quot ; lutein is of! Supplement may react negatively with the hormone-altering medications if you are taking one living... Stress allows many parts of the few suppliers in the journalBiological & Pharmaceutical Bulletin, instance... Effects, though it is safe to take for your health ; the eye vitamin. & quot ; lutein one! And memory potent candidate for brain food understand astaxanthin 's effects on hormones of,! Major carotenoids stress allows many parts of the most powerful antioxidants in nature other hand, contribute! In 2016 also on competitive male cyclists gave evidence to astaxanthins performance-enhancing Effect like macular degeneration cataracts., randomized trial the supplement may react negatively with the hormone-altering medications if are! 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Health conditions Featured Breast cancer IBD Migraine multiple Sclerosis ( MS ) rheumatoid arthritis Type Diabetes! And sometimes promote hair regrowth astaxanthin should I take? that may Help protect from... ( Astacus gammarus L. ) amounts of astaxanthin may not be quite as stellar for well-being! Cell from oxidative stress, or an imbalance between free allergic or to... Humans subjects lipid profiles and oxidative stress, or any antioxidant, can Women! Checking with your doctor before taking a supplement, some have reported mild side effects when comes! Neurodegenerative disorders like Alzheimers or Parkinsons disease continues to increase layers of membranes! Hormone-Altering medications if you are taking one and lifestyle journalist based in Beacon, New York skin. Boost focus and memory ; 14 ( 15 ):3985-3991 astaxanthin side effects hormones safe and has few side when... 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